Table 1.

Incubation periods for prion-inoculated Tg(Gfap-luc)/FVB mice treated with 2-AMTs

Inoculum	Treatment	Initiate dosing, dpi	Mean incubation period ± SEM, d	n/n0*	Survival index ± SEM
RML	Vehicle	—	118 ± 1	12/12	100†
	IND24	1	204 ± 5	12/12	173 ± 4
	IND24	60	211 ± 1	6/6	179 ± 1
RML	IND81	1	193 ± 3	11/11	164 ± 3
RML[IND24]‡	Vehicle	—	187 ± 13	9/9	158 ± 13
	IND24	1	166 ± 5	8/8	141 ± 5
RML[IND24]‡	Vehicle	—	188 ± 0	3/3	159 ± 1
	IND24	1	165 ± 5	5/5	140 ± 5
RML[IND24;IND24]	IND24	1	158 ± 0	5/5§	134 ± 1
RML[IND24;V]	Vehicle	—	113 ± 5	7/7	96 ± 5
ME7	Vehicle	—	126 ± 2	5/5	100†
	IND24	1	214 ± 4	9/9	170 ± 4
	IND24	60	158 ± 5	7/7	125 ± 5
ME7[IND24]	Vehicle	—	123 ± 1	8/8	98 ± 2
	IND24	1	183 ± 3	6/6	145 ± 3

^*n, number of ill mice; n₀, number of inoculated mice.

^†Vehicle-treated control used to calculate survival index.

^‡Inocula from two independent treatment experiments.

^§All mice showed clinical signs of prion disease, but were also suffering from an intercurrent peritonitis when euthanized.