Figure 4. Cross-dataset and cross-species comparisons reveals evolutionary conserved genome-wide chromosome organization.

(a) (top left) Scatter plot of E¹ for human vs. mouse in syntenic regions; (top right) comparison of observed between-species correlation of E¹ (r =.81, P < 1e-10) with GC-content stratified permuted data (r =.50, P < 1e-10); (bottom) human vs. syntenic mouse E¹ along human chr1; gaps in the mouse profile reflect regions of human chr1 without a corresponding syntenic region in mouse. Human E¹ is for TCC HindIII¹⁰ data, mouse E¹ was calculated for mouse Hi-C¹⁶ data. (b) Heatmaps of iteratively-corrected inter-chromosomal contact probability averaged over all chromosomal arm pairs; heatmaps show the natural log of the contact enrichment, re-scaled and re-binned to 80×80 map (see Online Methods). The data are for human lymphoblastoid Hi-C HindIII⁸, human lymphoblastoid TCC¹⁰, and mouse pro-B cell Hi-C^{16. 16}