Skip to main content
. Author manuscript; available in PMC: 2013 Nov 4.
Published in final edited form as: Am J Hematol. 2010 Feb;85(2):10.1002/ajh.21585. doi: 10.1002/ajh.21585

Table 1.

Characteristics of HEIRS Family Study participants*,

Family Study Participants by HFE Genotype

Characteristic Participants in C282Y/C282Y Proband Families (n = 666) Participants in Non-C282Y/C282Y Proband Families (n = 276) All Participants (n = 942)
Proband§ 103 (15) 68 (25) 171 (18)
 SF, TS screen positive 56 (8.4) 68 (25) 124 (13)
 SF, TS screen negative 47 (7.1) 0 (0) 47 (5.0)
Female 388 (58) 150 (54) 538 (57)
Race or Ethnicity
 Caucasian 642 (96) 81 (29) 723 (77)
 Asian 0 (0.0) 98 (36) 98 (10)
 Hispanic 17 (2.6) 58 (21) 75 (8.0)
 Other 7 (1.1) 38 (14) 45 (4.8)
HFE genotype
 C282Y/C282Y 206 (31) 4 (1.5) 210 (22)
 C282Y/H63D 53 (8.0) 16 (5.8) 69 (7.3)
 H63D/H63D 5 (0.8) 16 (5.8) 21 (2.2)
 C282Y/wt 288 (43) 35 (13) 323 (34)
 H63D/wt 34 (5.1) 45 (16) 79 (8.4)
 wt/wt 79 (12) 160 (58) 239 (25)
Menopause (% among women) 178 (46) 81 (54) 259 (48)
History of hepatitis 17 (2.6) 9 (3.3) 26 (2.8)
Phlebotomy treatment 57 (8.6) 4 (1.5) 61 (6.5)
CRP >0.5 mg/dL 173 (26) 49 (18) 222 (24)
Age (y) 48.2 ± 16.0 49.8 ± 15.9 48.7 ± 16.0
Alcohol consumption (gm/d) 8.3 ± 18.5 6.3 ± 16.8 7.7 ± 18.1
Body mass index 27.5 ± 5.5 27.3 ± 6.2 27.4 ± 5.7
SF (μg/L) median (IQR) 124.5 (51.0, 281.0) 208.5 (93.0, 370.5) 137.5 (59.0, 329.0)
TS (%) 42.9 ± 22.4 44.5 ± 16.0 43.4 ± 20.7
UIBC (μg/dL) 172 ± 84 163 ± 63 169 ± 79
*

Participants include both proband and non-proband family members from heritability analysis

Values are count and column percentage for categorical variables, mean ± standard deviation for continuous variables, except where median and interquartile range (IQR) are used, as noted.

Total sample size is n = 942. Depending on completeness of data, the sample size varied from 602 to 666 in C282Y/C282Y proband families, and from 236 to 276 in non-C282Y/C282Y proband families.

§

Three probands are excluded from the 174 families for analysis due to incomplete or inconsistent data for inclusion. Probands listed as screen positive are those for whom the TS and SF values were both above gender-specific cutoffs at the Initial Screening; screen negative are those for whom TS and SF values did not meet this criterion.