Table 3.

Genetic (r_G), and environmental (r_E) correlations between serum iron measures in families with HFE C282Y/C282Y probands

Proband	Measure 1*	Measure 2*	Model	N (Individuals)	rG Correlation (Standard error)	P† (ρG = 0)	P† (ρG = 1)	rE Correlation (Standard error) †	P† (ρE = 0)
C282Y/C282Y	TS	Ln SF	C	664	0.726 (0.114)	5.4×10−6	0.0038	0.344 (0.059)	<1×10−6
			D	596	0.759 (0.148).	0.00028	0.049	0.370 (0.065)	3.1×10−6
	TS	UIBC	C	664	−0.945 (0.033)	<1×10−6	0.035	−0.864 (0.019)	<1×10−6
			D	596	−0.955 (0.054)	6.7×10−6	0.21	−0.869 (0.020)	<1×10−6
	Ln SF	UIBC	C	664	−0.614 (0.102)	0.000011	1.1×10−6	−0.462 (0.058)	<1×10−6
			D	596	−0.544 (0.133)	0.0015	5.1×10−6	−0.504 (0.065)	<1×10−6

^*Model covariates: Model C (age, gender, age × gender, HFE genotype); Model D (age, gender, age × gender, HFE genotype, Field Center, body mass index, menopausal status, phlebotomy treatment, hepatitis, decile of alcohol intake, C-reactive protein); C282Y-H63D genotypes were coded as five indicator variables in all models. Field Centers were coded as four indicator variables in all models.

^†P values for two-sided tests of the genetic correlation between serum iron measures, ρ_G = 0 vs. ρ_G ≠ 0, and ρ_G = 1 vs. ρ_G ≠ 1.

^‡P values for two-sided tests of the environmental correlation between serum iron measures, ρ_E = 0 vs. ρ_E ≠ 0.