Table 4.
Results of testing for human papillomavirus (HPV) by PCR, Hybrid Capture 2 (HC2) and Pap smear relative to histology (40 women with high-grade lesiona, 26 with low-grade lesionb and 446 women with no lesionc).
| Specimen | Type of lesion |
Test index % (95% CI) for HSIL |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| High-grade | Low-grade | Otherc | Total | Sensitivity | Specificity | PPV | NPV | DA | |
| PCR-P | 35 | 9 | 23 | 67 | 87.5 (77.2, 97.8) | 93.2 (91.0, 95.5) | 52.2 (40.3, 64.2) | 98.9 (97.9, 99.9) | 92.8 (90.6, 95.0) |
| PCR-S | 33 | 8 | 22 | 63 | 82.5 (70.7, 94.3) | 93.6 (91.5, 95.9) | 52.4 (40.0, 64.7) | 98.4 (97.3, 99.6) | 92.8 (90.6, 95.0) |
| HC2-P | 36 | 8 | 31 | 75 | 90.0 (80.7, 99.3) | 91.7 (89.3, 94.2) | 48.0 (36.7, 59.3) | 99.1 (98.2, 100.0) | 91.6 (89.2, 94.0) |
| HC2-S | 32 | 7 | 49 | 88 | 80.0 (67.6, 92.4) | 88.1 (85.3, 91.1) | 36.4 (26.3, 46.4) | 98.1 (96.8, 99.4) | 87.5 (84.7, 90.4) |
| Pap≥ASCUS | 31 | 8 | 52 | 91 | 77.5 (61.1, 88.6) | 87.3 (83.9, 90.1) | 34.1 (24.7, 44.8) | 97.9 (95.8, 99.0) | 86.5 (83.5, 89.5) |
| Pap≥LSIL | 28 | 4 | 21 | 53 | 70.0 (53.3, 82.9) | 94.7 (92.2, 96.5) | 52.8 (32.8, 66.5) | 97.4 (95.4, 98.6) | 92.8 (90.6, 95.0) |
PPV: positive predictive value; NPV: negative predictive value; DA: diagnostic accuracy (true positive + true negative/total no. of cases); PCR-P: physician-collected sample tested by PCR; PCR-S: self-collected sample tested by PCR.
a
Women with high-grade lesion equivalent to CIN2, 3 or Ca was diagnosed by cervical biopsy.
b
Women with low-grade lesion equivalent to CIN1 was diagnosed by cervical biopsy.
c
Women with cervical biopsy indicated no SIL and women with normal cervix on colposcopy.