Fig. 3.

Changes in regional cerebral blood flow related tissue radioactivity in rats in response to 60-mmHg colorectal distension compared to 0-mmHg controls. Depicted is a selection of representative coronal slices (anterior–posterior coordinates relative to the bregma). Color-coded overlays show statistically significant positive (red) and negative (blue) differences of the 60-mmHg distension group compared to 0-mmHg controls (n = 12 each group, P < 0.05 at the voxel level, cluster >100 contiguous voxels). Line drawings have been adapted from those from the Paxinos and Watson (2005) rat atlas [59]: ASt (amygdalostriatal transition area), Au (auditory cortex), CA1 (hippocampus CA1 region), CeA (central n. of the amygdala), Cg1 (cingulate cortex area 1), CPu (caudate-putamen), I (insula), ic (internal capsule), Ect (ectorhinal cortex), LaA (lateral amygdala n.), M1, M2 (primary, secondary motor cortex), MD (medial thalamic n.), PAG (periaqueductal gray), PBN (parabrachial n.), PeFLH (perifornical part of the lateral hypothalamus), PF (parafascicular thalamus), Pn (Pons), PrL (prelimbic cortex), Po (posterior thalamic n.), PtA (parietal association area), RN (red n.), S1BF (primary somatosensory cortex, barrel field), S1FL (primary somatosensory cortex, forelimb), S1HL (primary somatosensory cortex, hindlimb), S2 (secondary somatosensory cortex), SC (superior colliculus), SN (substantia nigra), TeA (temporal association cortex), V1, V2 (primary, secondary visual cortex), VPL, VPM (ventral posterior lateral, ventral posterior medial thalamic n.). The left side of each coronal section represents the left side of the brain of the animal. Rat brain atlas figures were reproduced with modification from Paxinos and Watson [59] with permission.