Table 2.
Ruthenium catalyzed hydrohydroxyalkylation of styrenes 2g-2r and 3-hydroxy-2-oxindole 1a.a
| |||||
|---|---|---|---|---|---|
| entry | olefin | product | Ar moiety | branched:linear | yield (dr) |
| 1 | 2g | 3g (x-ray) | Ph | >20:1 | 94% (>20:1) |
| 2 | 2h | 3h | 2-napthyl | 13:1 | 81% (>20:1) |
| 3 | 2i | 3i | 4-Me-Ph | >20:1 | 83% (>20:1) |
| 4 | 2j | 3j | 4-OMe-Ph | >20:1 | 77% (>20:1) |
| 5 | 2k | 3k | 2-OMe-Ph | 1.3:1 | 91% (>20:1) |
| 6 | 2l | 3l | 4-NMe2-Ph | >20:1 | 65% (>20:1) |
| 7 | 2m | 3m | 1,3-benzodioxole | >20:1 | 81% (>20:1) |
| 8 | 2n | 3n | 4-CI-Ph | >20:1 | 82% (>20:1) |
| 9 | 2o | 3o | 4-CF3-Ph | >20:1 | 81% (>20:1) |
| 10 | 2p | 3p | 4-CN-Ph | 8.5:1 | 76% (>20:1) |
| 11 | 2q | 3q | 4-CO2Me-Ph | 4:1 | 87% (>20:1) |
| 12 | 2r | 3r | 2-Thienyl | >20:1 | 87% (>20:1) |
Yields are of material isolated by silica gel chromatography. C10H15CO2H refers to 1-adamantanecarboxylic acid. See Supporting Information for further details.