Table 1.
Clinical and metabolic characteristics of lean and obese adolescents
|
Characteristic
*
|
Lean control (n = 14)
|
Obese
|
P for trend
|
|
|---|---|---|---|---|
| NGT (n = 22) | IGR (n = 15) | |||
|
AGE (years) |
14.93 ± 0.64 |
15.45 ± 0.0.42 |
15.26 ± 0.54 |
0.63 |
|
Females |
64% |
72% |
73% |
0.85 |
|
Race/Ethnicity |
|
|
|
|
| Hispanic |
71.4% |
73% |
80% |
0.9 |
| AA |
21.4% |
18% |
20% |
|
| Others |
7% |
9% |
0% |
|
|
Weight (Kg) |
56.34 ± 2.49 |
98.42 ± 5.20 |
101.78 ± 4.86 |
0.64 |
|
WAIST (cm) |
75.98 ± 1.86 |
103.54 ± 3.20 |
110.45 ± 4.01 |
<0.001 |
|
BMI (kg/m
2
) |
22.69 ± 0.77 |
36.37 ± 1.89 |
37.44 ± 1.25 |
<0.001 |
|
SYSBP (mmHg) |
117.50 ± 3.31 |
118.14 ± 2.18 |
111.53 ± 2.24 |
0.19 |
|
DIASBP (mmHg) |
70.71 ± 2.41 |
68.31 ± 3.86 |
71.47 ± 2.47 |
0.99 |
|
Fasting Glucose (mg/dl) |
86.9 ± 4.00 |
82.36 ± 1.53 |
101.33 ± 4.51 |
0.001 |
|
HbA1C (%) |
5.55 ± 0.16 |
5.61 ± 0.09 |
5.77 ± 0.13 |
0.39 |
|
HOMA-IR |
1.75 ± 0.65 |
4.22 ± 0.56 |
10.42 ± 0.43 |
<0.001 |
|
TG (mg/dl) |
72.50 (53–97) |
81 (61–122) |
97 (62–164) |
0.09 |
| HDL (mg/dl) | 50.5 (41–58) | 41.5 (37–46) | 40 (36–52) | 0.21 |
Legend –AA—Africo-American, SYSBP—systolic BP, DYSBP—diastolic BP, HDL -- high density lipoprotein, TG—triglycerides, HOMA-IR-- homeostatic model assessment for insulin resistance: {fasting glucose (mg/dl)}{fasting insulin(μU/ml)}/40, NGT- fasting glucose level < 100 mg/dl and a 2 hour postprandial glucose level < 140 mg/d, IGR- fasting level ≥100 mg/dl and/or 2 hr ≥140. *Values are mean ± SE, median (IQR) or percent.