Figure 1.

Cumulative and derivative fragiligram for group 1a (IMHA), group 3 (hyperlipidemia) and group 6 (healthy dogs). The cumulative (dark line) and derivative (light line) fragiligrams are based on the mean values for OF5, OF50 and OF90 of group 1a (dogs with IMHA), group 3 (dogs with hyperlipidemia) and group 6 (healthy dogs) in the COFT. The figure shows a marked left shift of the cumulative and derivative fragiligram in dogs from group 1a, while no obvious left shift of the fragiligrams is present in dogs from group 3 or group 6. Furthermore, it can be noticed that the NaCl concentration at which 5% of the erythrocytes are haemolysed is higher for group 3 than for group 6, which indicates that in group 3 a small subpopulation of erythrocytes has an increased osmotic fragility.