Table 4.
Results of the rapid osmotic fragility test (ROFT) and classic osmotic fragility test (COFT) for group 1a (IMHA), group 1b (anaemia, no IMHA), group 2 (microcytosis), group 3 (hyperlipidemia), group 4 (lymphoma), group 5 (infections) and group 6 (healthy)
| . | Group 1a (n = 19) | Group 1b (n = 21) | Group 2 (n = 8) | Group 3 (n = 13) | Group 4 (n = 10) | Group 5 (n = 8) | Group 6 (n = 13) | |
|---|---|---|---|---|---|---|---|---|
|
ROFT |
Positive |
17 |
1 |
0 |
10 |
0 |
0 |
1 |
|
Negative |
2 |
20 |
8 |
3 |
10 |
8 |
12 |
|
| COFT |
OF5 |
0.75 ± 0.11* |
0.51 ± 0.11 |
0.53 ± 0.13 |
0.64 ± 0.14* |
0.52 ± 0.06 |
0.49 ± 0.04 |
0.51 ± 0.04 |
|
(%) |
(0.51-0.85) |
(0.37-0.83) |
(0.43-0.81) |
(0.43-0.84) |
(0.44-0.66) |
(0.44-0.52) |
(0.46-0.54) |
|
|
OF50 |
0.64 ± 0.12* |
0.39 ± 0.06 |
0.39 ± 0.05 |
0.45 ± 0.05 |
0.42 ± 0.04 |
0.39 ± 0.04 |
0.44 ± 0.03 |
|
|
(%) |
(0.44-0.83) |
(0.28-0.52) |
(0.35-0.49) |
(0.33-0.53) |
(0.36-0.47) |
(0.34-0.42) |
(0.40-0.49) |
|
|
OF90 |
0.38 ± 0.17 |
0.27 ± 0.10 |
0.26 ± 0.09 |
0.34 ± 0.07 |
0.36 ± 0.04 |
0.27 ± 0.10 |
0.34 ± 0.09 |
|
| (%) | (0.28-0.64) | (0.06-0.43) | (0.10-0.36) | (0.18-0.40) | (0.31-0.45) | (0.07-0.35) | (0.06-0.40) |
Data of the COFT are expressed as mean ± standard deviation (range).
OF5, OF50, OF90 are the NaCl concentration at which respectively 5, 50 and 90% of RBCs are hemolysed.
OF5, OF50 or OF90 from all clinical groups (group 1–5) were compared with the control group (group 6). The global significance level was set at 0.05.
*Denotes a statistically significant difference from the control group for the respective response variable.