Table 3.
Recurrence and death from disease after Mohs micrographic surgery
| Study and No of patients | Site | Follow-up | Proportion with outcome (95% CI) | Prognostic features* | ||||
|---|---|---|---|---|---|---|---|---|
| Local recurrence | Regional recurrence | Distant metastases | Unspecified recurrence | Patient died of disease | ||||
| Anderson 1982 (n=8) | Eyelid | Average 36 months (range 1-57) | 0.00 (0.00 to 0.37) | 0.12 (0.00 to 0.53) | 0.12 (0.00 to 0.53) | — | 0.12 (0.00 to 0.53) | No details |
| Brantsch 2008 (n=615) | All | Mean 43 months (range 1-165) | 0.03 (0.02 to 0.04) | 0.04 (0.03 to 0.06) | — | — | 0.01 (0.01 to 0.03) | Median diameter 15 mm, mean thickness 3 mm; differentiation: good (53%), moderate (22%), poor (25%); desmoplasia (8%); immunosuppression (5%) |
| Cherpelis 2002 (n=186) | Various | 6 months to 10 years | — | 0.08 (0.04 to 0.12) | — | — | — | Diameter >20 mm (20%); Clark level V (28%); poorly differentiated (9.5%); perineural invasion (4%) |
| Dzubow 1982 (n=171) | All | Mean 18.6 months (range 1-136) | 0.04 (0.01 to 0.07) | — | — | — | — | Diameter 1-9 mm (18.7%), 10-49 mm (68.7%), >50 mm (12.6%) |
| Leibovitch 2005 (n=229) | All | 5 years | 0.03 (0.01 to 0.06) | — | 0.00 (0.00 to 0.02) | — | — | Diameter <1 cm (25.6%), 1-1.9 cm (46.2%), 2-2.9 cm (15.4%), 3-3.9 cm (6.6%), 4-4.9 cm (2.3%), 5-5.9 cm (1%), 6-7.9 cm (0.5%), 8-10 cm (0.1%); differentiation: well (34.8%), moderate (36.4%), poor (6%); acantholytic (10.4%) |
| Malhotra 2004 (n=56) | Periocular | Mean 77.3 months | 0.04 (0.00 to 0.12) | — | — | — | — | Diameter 0-0.9 cm (57%), 1-1.9 cm (38%), 2-2.9 cm (5%); perineural invasion (4.3%) |
| Mohs 1976 (n=615) | Various | Up to 5 years | — | — | — | 0.01 (0.00 to 0.02) | — | No data |
| Pugliano-Mauro 2010 (n=231) | “High risk” | Mean 3.9 years | 0.01 (0.00 to 0.04) | 0.02 (0.00 to 0.04) | — | — | 0.00 (0.00 to 0.02) | “High risk”: diameter average 1.5 cm (standard deviation 0.7); immunosuppression (20%) |
| Silapunt 2005 (n=87) | Auricle | 2 years | 0.06 (0.02 to 0.13) | — | 0.00 (0.00 to 0.04) | — | 0.00 (0.00 to 0.04) | Average surface area 3.04 cm2 |
| Skaria 2010 (n=54) | Not specified | Mean 59.6 months | — | — | — | 0.02 (0.00 to 0.10) | — | No data |
| Thomas 2007 (n=66) | Various | Mean 45 months | — | — | — | 0.04 (0.01 to 0.13) | — | Mean size 3.9 cm2 |
| Tomsick 1984 (n=15) | Fingers | 5 months to 7 years | — | — | — | 0.00 (0.00 to 0.22) | — | 3 patients with SCC in area of chronic radiodermatitis |
| Turner 2000 (n=48) | All | Mean 3.4 years | 0.02 (0.00 to 0.11) | 0.04 (0.01 to 0.14) | 0.02 (0.00 to 0.11) | — | — | Median diameter 15 mm (range 3-40); median depth 2 mm (range 0.4-25); differentiation: grades 1 (37.2%), 2 (44.2%), 3 (14%), 4 (4.6%); vascular invasion (16%) |
| Van der Eerden 2010 (n=74) | Head and neck | Mean 24 months | 0.03 (0.00 to 0.09) | 0.01 (0.00 to 0.07) | — | — | — | No data |
| Vuyk 2001 (n=53) | Head and neck | Mean 33 months | 0.02 (0.00 to 0.10) | — | — | — | — | Poorly to well differentiated |
| Yoon 1992 (n=16) | External ear | 6 months to 20 years | — | — | — | 0.31 (0.11 to 0.59) | — | Stages 0-IV (only data for stage I-II included) |
*Percentages indicate proportion of patients in study.