Table 9.
Recurrence of SCCs after cryotherapy studies
| Study and No of SCCs | Site | Follow-up | Proportion (95% CI) of SCCs with recurrence | Prognostic features* | Study design |
|---|---|---|---|---|---|
| Fontana 1975 (n=7) | Unspecified | 32 months to 5 years | 0.00 (0.00 to 0.41) | No data | Retrospective |
| Fraunfelder 1980 (n=21) | Periocular | Average 21.6 months | 0.00 (0.00 to 0.16) | Diameter <10 mm (71%), ≥11 mm (29%) | Prospective |
| Graham 1990 (n=563) | All | Unspecified | 97.3% (“cure”†) | Diameter <5 mm (25%), 6-12 mm (56.4%), 13-24 mm (15.5%), >24 mm (3.1%) | Retrospective |
| Holt 1988 (n=34) | All | Range 6 months to 5.5 years | 0.03 (0.00 to 0.15) | Diameter >2 cm (14.7%); indeterminate margins, tethering, deeply invasive, and SCCs of external ear involving underlying cartilage excluded | Prospective |
| Kuflik 1986 (n=5) | Arms and hands | Range 12 months to 6 years | 0.00 (0.00 to 0.52) | Diameter: all 2-5 cm | Prospective |
| Kuflik 2004 (n=134) | All | 5 years | 0.00 (0.00 to 0.03) | Diameter 3-5 mm; “Only cases amenable to cryotherapy were treated” | Retrospective |
| Lindemalm-Lundstam 2009 (n=53) | Face and scalp | Mean 42 months | 0.00 (0.00 to 0.07) | Mean diameter 8 mm (range 1-76); lesions in area circumscribed by upper lip and nasolabial folds excluded | Prospective |
| Nordin 2002 (n=13) | External ear | ≤10 years (8 of 13 followed for at least 5 years) | 0.00 (0.00 to 0.25) | Mean diameter 18 mm (range 5-70) | Prospective |
| Peikert 2011 (n=6) | Below neck | 5 years | 0.00 (0.00 to 0.46) | Diameter: all <2 cm; no invasion beyond papillary dermis; spindle cell and poorly differentiated SCCs excluded | Prospective |
*Percentages indicate proportion of SCCs in study.
†“Cure” not defined.