Figure 1. .

Iris malformations in Fbn2-null mice. In WT mice, the pupil is circular and properly centered (A). Fbn2-null mice exhibited a range of iris defects including corectopia (B), dyscoria (C), iris hypoplasia/pseudopolycoria (arrowed in [D]), and typical coloboma (E). Mice deficient in both Fbn2 and Mfap2 generally exhibited more severe iris phenotypes (F). The mice shown are 1 to 2 months old except for (B) and (D), which are 10 months old.