Figure 2. .

Failure to sustain light-induced pupillary constriction in 2-month-old Fbn2^−/− mice. In Fbn2^−/− mice, corectopic pupils constrict initially in response to bright light (A). After 5 minutes in constant bright light, however, the pupil dilates (B), becoming unresponsive to further fluctuations in light intensity. Under the same illumination conditions, constriction is maintained in a WT mouse (C, D). Images are representative of six independent experiments.