Table.

Ocular Phenotypes in Adult (1–10 Months Old) WT and Mutant Mice

Genotype	No. Eyes Examined	Normal Appearance	Corectopia/Dyscoria	Iridal Coloboma
C57BL/6J (WT)	15	15	0	0
129Sv (WT)	16	16	0	0
Fbn2−/−	101	20	44	37
Fbn2−/−; Mfap2−/−	27	2	9	16
Mfap2−/−	16	16	0	0
Mfap5−/−	10	10	0	0
Mfap2−/−; Mfap5−/−	12	12	0	0

Mice deficient in Fbn2 were prone to iris malformations including corectopia, dyscoria, and coloboma. Mice deficient in Mfap2 and Mfap5 (genes encoding microfibril-associated glycoproteins) did not exhibit ocular symptoms.