Figure 5.
Homozygous Myo6tvrm89 mice display attenuated ERGs. Averaged strobe-flash ERG responses at 4 weeks (A–C), 8 weeks (D–F), and 1 year or older (G–I). (A, D, G) Averaged tracings from control (+/+ and tvrm89/+) and mutant (tvrm89/tvrm89) mice in response to stimuli of −2.4, −0.6, and 2.4 log cd s/m2. (B, E, H) The a-wave luminance-response functions (points indicate the average ± SEM). (C, F, I) The b-wave luminance-response functions (points indicate the average ± SEM). Data summarize results from 22 control and 10 mutants at 4 weeks, from 24 controls and 7 mutants at 8 weeks, and from 4 controls and 2 mutants at 1 year or older. ***P ≤ 0.0001, **P ≤ 0.001, *P ≤ 0.01 by Student's t-test.
