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Post-translational modifications of histone proteins H1, H2A, H2B, H3 and H4 involved in epigenetic regulation. Target amino acids for isomerization (
), phosphorylation (
), ubiquitination (
), acetylation (
) or methylation (
) are shown as one-letter code, together with the different enzymes able to add (in blue) each functional group. The histone demethylases are shown in red, besides the lysine residues susceptible to their specific enzymatic activity.
