Table 1.

Histone demethylases and their association with cancer development.

Histone demethylase	Genebank Acc. Number	Alteration	Associated cancer	References
LSD-1/KDM1A	NM_015013	Over-expression	ER-negative breast, Prostate, Leukemia, Sarcomas, Lung, neuroblastoma	[31,41,42,43,44,45,46,47,48,49]
		Low expression	Hepatocellular, gastrointestinal, Hepatobiliary and metastatic breast carcinomas	[50,51]
JARID1A/KDM5A	NM_001042603	Over-expression	Gastric, Leukemia	[52,53]
JARID1B/KDM5B	NM_006618	Over-expression	Testicular, Ovaries, Breast, Prostate, leukemia	[54,55,56,57,58,59,60,61]
JARID1C/KDM5C	NM_004187.3 NM_001146702.1	Over-expression	Renal Carcinoma, Cervical	[62,63,64]
JHDM1B/FBXL10/KDM2B	NM_032590	Over-expression/Mutation	Lymphomas, Acute myeloid leukemia	[65,66,67]
		Low expression	Gliobastoma multiforme, brain	[68]
JMJD2C/KDM4C	NM_015061; NM_001146694; NM_001146695; NM_001146696	Over-expression	MALT and Hodgkin Lymphomas, myeloid leukemia, Breast, gliobastoma multiforme, prostate, desmoplasic meduloblastoma, sarcomatoid and esophageal carcinoma.	[69,70,71,72,73,74,75,76,77,78,79,80,81,82]
JMJD2A/KDM4A	NM_014663	Over-expression	Kaposi Sarcoma, Prostate, Breast, Colon, Bladder.	[18,47,83,84,85,86,87]
JMJD3/KDM6B	NM_001080424	Over-expression	Colon, Lymphomas	[88,89,90]
UTX/KDM6A	NM_021140	Mutation/Low expression	Advanced forms of cancer, Multiple mieloma, Leukemia, renal and bladder carcinomas.	[91,92,93,94,95,96]