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Subunit structure of voltage gated calcium channels (VGCC). The α1 is the pore-forming subunit which contains voltage-sensing machinery and the binding sites of channel blockers. α1 subunit contains 4 homologous domains (I–IV), each containing 6 transmembrane helices (S1–S6). The α2δ and β subunits enhance expression and modulate the voltage dependence and gating kinetics of VGCCs.
