. Author manuscript; available in PMC: 2013 Nov 4.

Published in final edited form as: Bioorg Med Chem. 2011 Feb 2;19(6):10.1016/j.bmc.2011.01.060. doi: 10.1016/j.bmc.2011.01.060

Table 1.

Inhibitory potencies of 9-amido analogs (5-7) for mCD22 and hCD22.

Compd.	Activity
	mCD22⁷		hCD22

	IC₅₀ (μM)^a	rIP^b	IC₅₀ (μM)	rIP
1	3.84 ± 0.32	1	0.90 ± 0.00	1
5	0.10 ± 0.00	38.4	0.13 ± 0.00	7
6	0.19 ± 0.00	20.2	0.07 ± 0.01	12
7	5.00 ± 0.6	0.77	ND

Sialoside concentration which leads to 50% inhibition of binding. The values are the mean ± SD of triplicates.

The rIP of each sialoside was calculated by dividing the IC₅₀ of the reference compound 1 by the IC₅₀ of the compound of interest. The results in rIPs above 1.0 for derivatives binding better than the reference and rIPs below 1.0 for compounds with a lower affinity than the reference.

ND; not determined. The values for mCD22 and hCD22 cannot be directly compared