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(a) The last 30 amino acids in human p53 (aa 363–393) showing the sites specifically modified by ubiquitination (Ub), acetylation (Ac), methylation (Me), neddylation (Ne), sumoylation (SUMO), and phosphorylation (P). (b) Sumoylation of p53 at Lys-386 enhances Ser-392 phosphorylation by PKR but inhibits Lys-382 acetylation by p300/CBP.
