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. 2013 Nov 1;5:45. doi: 10.12703/P5-45

Figure 4. Deregulation of microphthalmia-associated transcription factor (MITF) sumoylation is associated with predisposition to melanoma and renal cell carcinoma.

Figure 4.

MITF possesses two sumoylation sites, Lys-182 and Lys-316, flanking the DNA-binding domain, Lys-182 and Lys-316, with the latter being the major one. The E318K substitution impairs Lys-316 sumoylation and leads to increased risk of melanoma and renal carcinoma. aa, amino acids.