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. Author manuscript; available in PMC: 2013 Nov 4.
Published in final edited form as: J Neurosci Res. 2009 Feb 15;87(3):10.1002/jnr.21889. doi: 10.1002/jnr.21889

Fig. 2.

Fig. 2

The effect of WIN2 is concentration dependent and solely involves CB1. A: fEPSP recordings obtained after a 35-min exposure to various concentrations of WIN2. Top: A WIN2 concentration of 0.01 μM did not alter excitatory transmission, but a clear effect was observed with 0.1 μM. Middle: The maximal effect was obtained with 1 μM WIN2, insofar as increasing the dose to 4 μM did not further alter fEPSPs. Bottom: The CB1 antagonist AM251 completely prevented the effect of the highest concentration of WIN2, confirming the sole involvement of CB1. B: Dose-response curve (logistic fit) of the WIN2 effect. WIN2 decreased fEPSPs by a maximum of 62%, with an apparent EC50 of 0.2 μM (dashed line). WIN2 did not affect fEPSPs in the presence of SR1 (open circle) or AM251 (open triangles).