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. Author manuscript; available in PMC: 2013 Nov 4.
Published in final edited form as: J Neurosci Res. 2009 Feb 15;87(3):10.1002/jnr.21889. doi: 10.1002/jnr.21889

Fig. 7.

Fig. 7

Summary of cannabinoid effects on excitatory transmission. A: AEA alone or in the presence of the transport inhibitor AM404 did not significantly affect fEPSPs. Inhibition of FAAH with AM374 or URB597 potentiated the effect of AEA to a level similar to the effect of mAEA. The effect of mAEA was completely prevented by the CB1 antagonist AM251. Asterisks denote statistical significance compared with pre-AEA values (n.s., no statistical significance). B: The cannabinoid 2-AG did not significantly alter fEPSPs whether applied alone or in the presence of the MAGL inhibitors URB602 or NAM. However, the combined application of 2-AG and the COX-2 inhibitor NS398 significantly decreased fEPSPs, an effect largely prevented by AM251. C: WIN2 had a very large effect in decreasing synaptic transmission. The effect of WIN2 was completely prevented by the CB1 antagonists SR1 or AM251. Asterisks denote statistical significance relative to control (no drug) values.