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At top, mitochondria are intermittently involved in fusion, mediated by mitofusins (MFNs) and fission, mediated by DRP1. The rates of these processes are impacted by starvation and stress, as indicated on the left and right-hand side, respectively. Both decreased fission and increased fusion will result in mitochondrial elongation, at bottom. Reprinted by permission from Macmillan Publishers Ltd: Nature Cell Biology, [91], copyright 2011.
