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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Biomaterials. 2013 Jun 12;34(28):10.1016/j.biomaterials.2013.05.010. doi: 10.1016/j.biomaterials.2013.05.010

Scheme 1.

Scheme 1

The triblock polymer PEG-b-PAsp(DET)-b-PCL was synthesized via a two step ring-opening polymerization. More specifically, PEG5k–NH2 was used as a macroinitiator to polymerize BLA-NCA to yield amine-terminated PEG-b-PBLA-NH2. Next, the terminal amino group of PEG-b-PBLA-NH2 was used as an initiator for the polymerization of ε-cap-rolactone to yield PEG-b-PBLA-b-PCL. Finally, to obtain the triblock polymer, the side chains of the PBLA block were substituted with DET groups by an aminolysis reaction.