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Relationship between HIC estimated as HICISR (C and D) and HICC-peptide (A and B) and OGTT-derived indices of insulin secretion (1st-phase insulin secretion index [IS] [26]) in the entire cohort (n = 800; subjects with metabolic syndrome, n = 325; subjects without metabolic syndrome, n = 475). R2 was calculated for linear and nonlinear restricted cubic spline regression models.
