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. 2013 Oct 15;36(11):3396–3404. doi: 10.2337/dc12-2673

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Effect of empagliflozin on efficacy parameters. A: HbA_1c over time in randomized groups (mixed model repeated measures, FAS, and OC). B: Change from baseline in HbA_1c at week 24 in randomized groups (ANCOVA, FAS, and LOCF imputation). C: HbA_1c over time in the open-label treatment group (OC and descriptive statistics). D: Change from baseline in MDG at week 24 in randomized groups (ANCOVA, FAS, and OC). E: Change from baseline in weight at week 24 (ANCOVA, FAS, and LOCF). F: Change from baseline in SBP at week 24 (ANCOVA, FAS, and LOCF). G: Change from baseline in DBP at week 24 (ANCOVA, FAS, and LOCF). Data are adjusted mean (SE) for randomized groups and mean (SE) for open-label treatment group. *P < 0.001 vs. placebo; †P = 0.032 vs. placebo; ‡P = 0.005 vs. placebo; §P = 0.557 vs. placebo; ¶P = 0.534 vs. placebo.

Effect of empagliflozin on efficacy parameters. A: HbA_1c over time in randomized groups (mixed model repeated measures, FAS, and OC). B: Change from baseline in HbA_1c at week 24 in randomized groups (ANCOVA, FAS, and LOCF imputation). C: HbA_1c over time in the open-label treatment group (OC and descriptive statistics). D: Change from baseline in MDG at week 24 in randomized groups (ANCOVA, FAS, and OC). E: Change from baseline in weight at week 24 (ANCOVA, FAS, and LOCF). F: Change from baseline in SBP at week 24 (ANCOVA, FAS, and LOCF). G: Change from baseline in DBP at week 24 (ANCOVA, FAS, and LOCF). Data are adjusted mean (SE) for randomized groups and mean (SE) for open-label treatment group. *P < 0.001 vs. placebo; †P = 0.032 vs. placebo; ‡P = 0.005 vs. placebo; §P = 0.557 vs. placebo; ¶P = 0.534 vs. placebo.