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. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Neuron. 2013 Sep 18;79(6):10.1016/j.neuron.2013.08.032. doi: 10.1016/j.neuron.2013.08.032

Figure 4. Behavioral characterization of mice overexpressing TET1 and TET1m in the dorsal hippocampus.

Figure 4

(A) Total distance traveled during 15 min in the open field. (B) The ratio of time spent in the center versus time spent in the periphery of the open field, a measure of anxiety. (C) Shock threshold test. (D) Percent of time freezing before and after presentation of the foot shock during the 3 min training session. (E) Percent of time freezing during a 5 min context test, 1 h after training. For experiments A–C, E n = 9 for all groups. (F) Percent of time freezing during a 5 min context test, 24 h after training (F2, 58 = 7.185). YFP vs. TET1 and TET1m. **p < 0.01, *p < 0.05; one-way ANOVA followed by Bonferroni post hoc test. For experiments D and F; AAV-YFP (n = 17), AAV-TET1 (n = 21), AAV-TET1m (n = 21). All data are presented as mean ± s.e.m.