Table 2.
Outcomes Data From Study Registration
| Patient Group | No. of Patients | OS (months) | PFS (months) | 2-Year Survival Rate (%) |
|---|---|---|---|---|
| All eligible | 1,120 | 16.0 | 7.5 | |
| All randomly assigned | 833 | 17.7 | 8.2 | |
| Arm 1 | 411 | 18.9 | 7.5 | 34.2 |
| Arm 2 | 422 | 16.8 | 8.8 | 33.9 |
| MGMT | ||||
| Methylated | 245 | 23.2 | 10.5 | 47.3 |
| Unmethylated | 517 | 16.0 | 7.8 | 25.4 |
| Methylated | ||||
| Arm 1 | 122 | 23.5 | 8.8 | |
| Arm 2 | 123 | 21.9 | 11.7 | |
| Unmethylated | ||||
| Arm 1 | 254 | 16.6 | 7.1 | |
| Arm 2 | 263 | 15.4 | 8.2 |
Abbreviations: MGMT, O6-methylguanine-DNA methyltransferase; OS, overall survival; PFS, progression-free survival.