Figure 2.

Combined miRNAs and transcription factor regulation of inflammation in wound healing. (a) The “seed” miRNA regulatory network built with data from Table 1 of Roy and Sen.⁵ (b) Integrated regulatory network built by using Pathway Studio 9.0 software, which added three more miRNAs (highlighted in yellow), 13 transcription factors, 7 receptor proteins, and 5 other proteins and their relations. The proteins highlighted in blue and the miRNA in red represent the seed set. Relation colors: red, miRNA regulation; green, promoter binding; black, direct regulation; dotted line, indirect regulation. To see this illustration in color, the reader is referred to the web article at www.liebertpub.com/wound