Skip to main content
. 2013 Oct 30;8:523–532. doi: 10.2147/COPD.S52637

Table 2.

Relationships between airway dimensions and pulmonary function in COPD

Variable FEV1, %a, rb P-value MEF75, %a, rb P-value MEF50, %a, rb P-value MEF25, %a, rb P-value
%LAA
 Peripheral zone −0.68 <0.0001 −0.706 <0.0001 −0.681 <0.0001 −0.593 <0.0001
 Middle zone −0.601 <0.0001 −0.675 <0.0001 −0.673 <0.0001 −0.581 <0.0001
 Central zone −0.494 <0.0001 −0.54 <0.0001 −0.533 <0.0001 −0.454 <0.0001
 Total zone −0.621 <0.0001 −0.673 <0.0001 −0.661 <0.0001 −0.57 <0.0001
Airways, n
 Peripheral zone 0.618 <0.0001 0.687 <0.0001 0.74 <0.0001 0.722 <0.0001
 Middle zone 0.56 <0.0001 0.663 <0.0001 0.708 <0.0001 0.68 <0.0001
 Central zone 0.074 NS 0.07 NS 0.054 NS 0.091 NS
 Total zone 0.599 <0.0001 0.682 <0.0001 0.724 <0.0001 0.713 <0.0001
Vessels, No
 Peripheral zone 0.47 <0.0001 0.583 <0.0001 0.625 <0.0001 0.599 <0.0001
 Middle zone 0.524 <0.0001 0.613 <0.0001 0.63 <0.0001 0.571 <0.0001
 Central zone 0.466 <0.0001 0.537 <0.0001 0.547 <0.0001 0.499 <0.0001
 Total zone 0.524 <0.0001 0.624 <0.0001 0.649 <0.0001 0.602 <0.0001
Airway inner diameter, mm
 Peripheral zone 0.614 <0.0001 0.612 <0.0001 0.569 <0.0001 0.542 <0.0001
 Middle zone 0.667 <0.0001 0.649 <0.0001 0.614 <0.0001 0.561 <0.0001
 Central zone 0.466 <0.0001 0.659 <0.0001 0.606 <0.0001 0.537 <0.0001
 Total zone 0.723 <0.0001 0.71 <0.0001 0.563 <0.0001 0.603 <0.0001

Notes:

a

Predicted;

b

Pearson correlation coefficients (r) are expressed for spirometric parameters and their relationship to the area of emphysema (%LAA), number of airways, number of vessels, and airway inner diameter of 3 mm circles. Around the airway at the peripheral zone (2 cm from the pleura), the central zone (2 cm from the entrance to the segmental bronchus), and the middle zone (half-way point between the central and peripheral zones). The averages of image parameters of right B1 to right B10 are used.

Abbreviations: FEV1, forced expiratory volume in one second; %LAA, percentage of low attenuation area; MEF25, maximum expiratory flow at 25% forced vital capacity; MEF50, maximum expiratory flow at 50% forced vital capacity; MEF75, maximum expiratory flow at 75% forced vital capacity; NS, not statistically significant.