Table 1.

Average accumulated radioactive material percentage–time profile of 3 main organs of male and female Sprague Dawley rats (n=5 for each sex, mean ± standard deviation)

	Liver (%)		Spleen (%)		Kidney (%)
	Male	Female	Male	Female	Male	Female
[14C]-SPION
0.5 h	9.31 ± 0.84	5.79 ± 4.36	0.44 ± 0.03	0.36 ± 0.30	2.54 ± 0.10	2.06 ± 0.69
1 h	11.43 ± 0.74	11.43 ± 3.20	0.32 ± 0.13	0.32 ± 0.17	2.25 ± 0.52	2.25 ± 0.60
4 h	13.18 ± 2.20	13.18 ± 0.33	0.67 ± 0.14	0.67 ± 0.20	3.00 ± 0.38	3.00 ± 0.38
12 h	16.32 ± 1.57	15.29 ± 0.12	0.73 ± 0.06	0.71 ± 0.18	3.70 ± 0.63	2.66 ± 0.60
1 day	11.83 ± 2.74	15.89 ± 0.17	0.46 ± 0.15	0.80 ± 0.19	2.33 ± 1.14	3.23 ± 0.55
5 days	11.13 ± 1.03	11.42 ± 0.99	0.40 ± 0.05	0.55 ± 0.10	2.06 ± 0.20	2.48 ± 0.40
10 days	4.51 ± 1.12	4.58 ± 0.38	0.22 ± 0.08	0.30 ± 0.06	0.90 ± 0.21	1.03 ± 0.15
[59Fe]-SPION
0.5 h	65.83 ± 2.26	67.78 ± 2.25	2.24 ± 0.34	2.67 ± 0.27	0.90 ± 0.17	0.80 ± 0.18
1 h	72.53 ± 2.33	73.47 ± 2.37	2.44 ± 0.49	3.20 ± 0.55	0.58 ± 0.11	0.57 ± 0.24
4 h	82.10 ± 3.29	81.89 ± 4.01	3.01 ± 0.22	3.07 ± 0.67	0.43 ± 0.04	0.28 ± 0.02
12 h	75.82 ± 3.42	80.57 ± 2.53	2.69 ± 0.44	3.50 ± 0.42	0.39 ± 0.03	0.50 ± 0.34
1 day	80.04 ± 1.40	85.68 ± 2.75	2.58 ± 0.34	3.70 ± 0.66	0.43 ± 0.04	0.34 ± 0.05
5 days	61.31 ± 3.23	69.16 ± 1.53	1.24 ± 0.17	2.83 ± 0.58	0.64 ± 0.14	0.82 ± 0.28
10 days	52.23 ± 4.42	66.83 ± 2.54	1.33 ± 0.17	2.45 ± 0.44	0.85 ± 0.13	1.10 ± 0.14
20 days	46.09 ± 2.73	48.75 ± 1.98	0.87 ± 0.10	1.88 ± 0.39	1.29 ± 0.19	1.33 ± 0.15
30 days	40.73 ± 6.00	42.69 ± 3.66	1.29 ± 0.55	1.73 ± 0.35	1.21 ± 0.35	1.09 ± 0.24
50 days	11.93 ± 4.80	17.87 ± 2.61	1.47 ± 0.34	1.76 ± 0.41	0.86 ± 0.17	0.99 ± 0.19

Abbreviations: h, hours; n, number; SPION, superparamagnetic iron oxide nanoparticles.