Table 2.

Pharmacokinetic parameter obtained by intravenous injection of [¹⁴C]-SPION and [⁵⁹Fe]-SPION in the liver of Sprague Dawley rats (n=5 for each sex, mean ± standard deviation)

Liver	[14C]-SPION		[59Fe]-SPION
	Male	Female	Male	Female
Tmax (h)	12	24	4	4
Cmax (%)	16.32 ± 1.57	17.82 ± 2.04	80.04 ± 1.40	85.70 ± 2.71
t1/2 (day)	6.31 ± 2.04	5.02 ± 2.06	21.62 ± 4.46	23.40 ± 3.71

Abbreviations: h, hours; SPION, superparamagnetic iron oxide nanoparticles; n, number.