Figure 3. Lack of aminoacylation inhibition in presence of N-methylated leucyl- (2) and glycyl-sulfamoyladenosine (3) as potential inhibitors.

Established aminoacyl-sulfamoyl-adenosines (Leu-SA, Gly-SA, Ala-SA and Pro-SA), that were previously shown to be potent inhibitors of their respective aaRSs, were used as positive controls. All experiments were performed in triplicate.