Table 1.
Patient characteristics
| Case 1 | Case 2 | Case 3 | Case 4 | |
|---|---|---|---|---|
| Age/sex | 53/male | 28/female | 59/female | 39/male |
| Underlying disease | ALL | AML | CML | NHL |
| Conditioning regimen | Myeloablative Cytoxan/TBI | Myeloablative Cytoxan/TBI | Myeloablative Cytoxan/TBI | Nonmyeloablative fludarabine/busulfan |
| Donor sex/relation | Male/unrelated | Male/unrelated | Male/related | Female/related |
| Donor HLA status | Matched 6/6 | Matched 5/6 | Matched 5/6 | Matched 6/6 |
| Date of HSCT | 12/18/2008 | 4/4/2008 | 8/22/1997 | 2/15/2006 |
| Transplant type | PBSCT | PBSCT | BMT | PBSCT |
| GVHD prophylaxis | Tacrolimus, sirolimus | Prednisolone, tacrolimus, sirolimus | Cyclosporine | Cyclosporine |
| GVHD manifestations | Skin, liver, eyes | Liver, lungs, eyes | Eyes | Skin, liver, eyes |
| Days from HSCT to ocular | 447 | 445 | 4,897 | 115 |
| GVHD diagnosis | ||||
| Days from HSCT to ulceration | OD: 1,287 | OD: 670 | OD: 5,065 | OD: 1,910 |
| OS: 881 | OS: 1,315 | OS: 5,155 | OS: 1,919 | |
| Days from HSCT to perforation | OS: 901 | OD: 670 | NA | NA |
| Culture results | Staphylococcus aureus | Hemolytic streptococci | NA | NA |
| Visual acuity at presentation | OD: 20/100 | OD: 20/200 | OD: 20/40 | OD: 20/400 |
| OS: CF @ 1 foot | OS: 20/300 | OS: 20/100 | OS: 20/200 | |
| Visual acuity at last follow-up visit | OD: 20/30 | OD: 20/30 | OD: 20/30 | OD: hand motion |
| OS: 20/400 | OS: 20/30 | OS: 20/30 | OS: 20/80 | |
| Duration of topical corticosteroids before ulceration | Unknown | OD: 2 weeks | OD: NA | NA |
| OS: 3 weeks | OS: 1 week | |||
| Duration of oral corticosteroids before ulceration | 2 months | 15 months | NA | 60 months |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; NHL, non-Hodgkin’s lymphoma; CML, chronic myeloid leukemia; TBI, total body irradiation; HLA, human leukocyte antigen; HSCT, hematopoietic stem cell transplantation; PBSCT, peripheral blood stem cell transplantation; BMT, bone marrow transplantation; GVHD, graft-versus-host disease; OD, right eye; OS, left eye; CF, count fingers; NA, not applicable.