Figure 10. KD-induced neuroprotective effect is lost in when MCT transport is inhibited using α-cyano-4-hydroxy-cinnamate (4-CIN).

At day 7-post injury, the total lesion volume (Cavalieri’s Estimator of Morphometric Volume) was decreased in spinal cords of KD fed animals compared to the standard diet group (SD). However, no difference in lesion volume between both groups was observed when animals were treated for 7 days with the MCT inhibitor 4-CIN. Error bars indicate SEM. # p=0.057 (t-test, one tailed).