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. 2013 Nov 4;8(11):e78765. doi: 10.1371/journal.pone.0078765

Table 3. Overview of the experimental studies.

Exp.
Groups Species Treatment duration Outcome parameters
1 n=10 1) 3:1KD Sprague Dawley 0-14 wpi Body weight, blood parameters
n=9 2) SD Behavior: cylinder rearing, grooming test
Histology: lesion area, tissue sparing
2 n=18 1) 3:1KD > SD Sprague Dawley 0-12 wpi * Behavior: Cylinder rearing, grooming test, Montoya staircase, Whishaw reaching
n=18 2) SD *12-16 wpi Switched back to SD
3 n=13 1) 3:1KD Sprague Dawley 0-12 wpi Behavior: Montoya staircase
n=14 2) SD
4 n=4 1) 3:1KD Sprague Dawley 0-7 dpi Histology: Immunofluorescence for MCT1 and GLUT1
n=5 2) SD
5 n=4 1) 3:1KD Sprague Dawley 0-14 dpi Biochemical: RT-PCR for BDNF, PDGFβ, VEGF, HIF1α, SDF1α
n=4 2) SD
6 n=4 1) 3:1KD Sprague Dawley 0-14 dpi Biochemical: Western Blotting for MCT1
n=5 2) SD
7 n=5 1) 3:1KD C57Bl/6 0-7 dpi Histology: Tissue sparing
n=4 2) SD
n=6 3) 3:1KD+4-CIN
n=6 4) SD+4-CIN

Abbreviations: BDNF, brain-derived neurotrophic factor; dpi: days post spinal cord injury; 4-CIN, Alpha-cyano-4-hydroxycinnamic acid (MCT1 inhibitor); GLUT1: glucose transporter-1; HIF1α, hypoxia-inducible factor-1α; KD: ketogenic diet; MCT1: monocarboxylate transporter isoform 1; PDGFβ, platelet-derived growth factor-β; SD: standard diet; SDF1α, stromal cell-derived factor -1α; VEGF, vascular endothelial growth factor; wpi: weeks post spinal cord injury.

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