Table 3. Overview of the experimental studies.
Exp.
|
Groups | Species | Treatment duration | Outcome parameters | |
---|---|---|---|---|---|
1 | n=10 | 1) 3:1KD | Sprague Dawley | 0-14 wpi | Body weight, blood parameters |
n=9 | 2) SD | Behavior: cylinder rearing, grooming test | |||
Histology: lesion area, tissue sparing | |||||
2 | n=18 | 1) 3:1KD > SD | Sprague Dawley | 0-12 wpi * | Behavior: Cylinder rearing, grooming test, Montoya staircase, Whishaw reaching |
n=18 | 2) SD | *12-16 wpi Switched back to SD | |||
3 | n=13 | 1) 3:1KD | Sprague Dawley | 0-12 wpi | Behavior: Montoya staircase |
n=14 | 2) SD | ||||
4 | n=4 | 1) 3:1KD | Sprague Dawley | 0-7 dpi | Histology: Immunofluorescence for MCT1 and GLUT1 |
n=5 | 2) SD | ||||
5 | n=4 | 1) 3:1KD | Sprague Dawley | 0-14 dpi | Biochemical: RT-PCR for BDNF, PDGFβ, VEGF, HIF1α, SDF1α |
n=4 | 2) SD | ||||
6 | n=4 | 1) 3:1KD | Sprague Dawley | 0-14 dpi | Biochemical: Western Blotting for MCT1 |
n=5 | 2) SD | ||||
7 | n=5 | 1) 3:1KD | C57Bl/6 | 0-7 dpi | Histology: Tissue sparing |
n=4 | 2) SD | ||||
n=6 | 3) 3:1KD+4-CIN | ||||
n=6 | 4) SD+4-CIN |
Abbreviations: BDNF, brain-derived neurotrophic factor; dpi: days post spinal cord injury; 4-CIN, Alpha-cyano-4-hydroxycinnamic acid (MCT1 inhibitor); GLUT1: glucose transporter-1; HIF1α, hypoxia-inducible factor-1α; KD: ketogenic diet; MCT1: monocarboxylate transporter isoform 1; PDGFβ, platelet-derived growth factor-β; SD: standard diet; SDF1α, stromal cell-derived factor -1α; VEGF, vascular endothelial growth factor; wpi: weeks post spinal cord injury.