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. 2013 Oct 30;6:1545–1552. doi: 10.2147/OTT.S32545

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© 2013 Noel and Hezel. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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Pathways and targeted therapy in BTC.

Notes: Drugs in red lettering represent agents that have been evaluated in trials that are now complete. Drugs in blue lettering represent agents that are in trials that are currently enrolling.

Abbreviations: BTC, biliary tract cancer; PDGFR, platelet-derived growth factor receptor; EGFR, epidermal growth factor receptor; HER-2, human epidermal growth factor receptor 2; VEGFR, vascular endothelial growth factor receptor; AKT, protein kinase; mTOR, mammalian target of rapamycin; MEK, mitogen-activated protein kinase.