Table 1.

Common mutations in biliary tract cancer

Gene	IHCC	EHCC	GB	References
KRAS	9%–54%	10%–22%	3%–38%	22–25
EGFR	10%–20%	5%–15%	9%–38%	33–36
PIK3A	5%–9%		4%	37, 38
BRAF	0%–22%	0%	0%–33%	26, 29
IDH1/IDH2	28%	7%		40–42
ERBB2/HER-2	0%–10%	5%–26%	16%	60

Abbreviations: IHCC, intrahepatic cholangiocarcinoma; EHCC, extrahepatic cholangiocarcinoma; GB, gallbladder carcinoma; HER-2, human epidermal growth factor receptor 2.