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. 2013 Nov 4;8(11):e79841. doi: 10.1371/journal.pone.0079841

Figure 3. Enhanced Nrf2 activity attenuates Pparα signaling induction and decreases lipogenic gene expression in liver by fasting.

Figure 3

(A) The induction of Cyp4a14 and CPT 1a by fasting was attenuated in liver of Keap1-KD (KD) mice. (B, C) Immunoblot analysis of Pparα in liver from fed or fasted C57BL/6 (WT) and Keap1-KD (KD) mice. (D)The expression of lipogenic genes, such as Fas, Acc1, and Scd1, was decreased in liver of Keap1-KD (KD) mice compared to C57BL/6 (WT) mice by fasting (n=4-6 per group). *, P<0.05, WT-Fasted compared with WT-Fed mice; #, P<0.05, KD-Fasted compared with KD-Fed mice; §, P<0.05, KD-Fasted compared with WT-Fasted mice.