Table 1. Plasma amino acid analysis of mice from different age groups (pooled) measured at humane endpoint.

		Vehicle-treated mice	Tamoxifen-treated mice	P value
BCAA	Valine	204±17.5	124±8.0	<0.001
	Isoleucine	71.7±4.0	51.9±4.1	<0.01
	Leucine	146±13.4	98.0±7.3	<0.01
Aromatic	Phenylalanine	108±13.2	90.7±4.2	NS
	Tryptophan	94.6±11.3	83.7±7.9	NS
	Tyrosine	79.2±11.3	55.3±3.7	NS
Heterocyclic	Proline	99.1±7.3	52.6±2.0	<0.001
Carboxamide	Asparagine	56.1±9.4	30.3±1.2	<0.05
	Glutamine	700±38.8	684±29.7	NS
Hydroxy	Serine	147±13.9	81.8±3.5	<0.001
	Threonine	188±13.1	89.0±3.6	<0.001
Monoamino, monocarboxylic	Alanine	451±37.3	211±19.0	<0.001
	Glycine	244±18.7	138±6.7	<0.001
Diamino, monocarboxylic	Histidine	97.6±14.3	72.5±4.4	NS
	Lysine	318±31.1	342±41.5	NS
Monoamino, dicarboxylic	Aspartic acid	19.6±1.6	17.9±2.0	NS
	Glutamic acid	54.9±6.0	44.4±5.4	NS
Urea cycle-related	Arginine	100±7.9	784±62.1	<0.001
	Citrulline	61.4±2.7	89.7±4.5	<0.001
	Ornithine	78.7±7.5	70.0±20.5	NS
Thioether	Methionine	81.2±8.1	43.0±3.7	<0.001
Guanidino compound	Guanidino acetic acid	1.2±0.1	2.8±0.3	<0.001

Values are mean ± SEM for n = 11–12 and are expressed as micromoles per liter (µmol/L). BCAA, branched chain amino acid; NS, not significant.