Figure 6. hAIM increases the expression of the antimicrobial peptides DEFB4 and cathelicidin.

A) Stably transfected THP1 MФ were infected with M. tuberculosis at MOI 0.1, and mRNA levels of DEFB4 and cathelicidin were determined by RT-qPCR. B) The same experiment was performed but cells were incubated with rIFNγ (10 ng/ml) 24 h prior to infection. mRNA mean fold change values is relative to uninfected THP1-Vector ± SEM, set as 1, from three independent experiments. *p≤0.05; **p≤0.01; ***p≤0.001 two-way ANOVA.