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. 2013 Jul 23;10(8):1291–1298. doi: 10.4161/rna.25827

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Copyright © 2013 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name rna-10-1291-g5.jpg — Figure 5. MAGOH and MAGOHB collectively support NMD. (A and B) The effect of single or combined knockdowns of MAGOH and MAGOHB on NMD was determined. The levels of the known cellular NMD-substrates SC35 1.6 kb (A) SC35 1.7 kb (B) were measured by quantitative RT-PCR and normalized to TBP. Fold upmodulation compared with Luc-siRNA transfected cells is depicted. Values for Y14-depleted cells are shown as separate panel. (C) Both MAGOH and MAGOHB are incorporated into the EJC core. Hence, two different types of core EJCs (MAGOH-containing and MAGOHB-containing) are formed in mammalian cells.