Figure 6. Folate deficiency-induced cell death and apoptosis was shown to be characteristically associated with DNA fragmentation, as demonstrated by either by the nucleosomal DNA fragmentation of 180–200 base pair multimers performed by gel electophoresis (B) or by drastic increase in the terminal transferase-mediated fluorescein-12-dUTP-labeled fragmented DNA (TUNEL-positive) of apoptotic cells detected flowcytometrically (C).