Figure 8. Folate deficiency simultaneously induces an impediment of insulin- synthesizing ability and insulin secretion in response to glucose challenge in RINm5F cells.

(A) Direct quantification of insulin by a chemiluminesent microparticle immunoassay (CMIA) kit revealed that FD condition could hamper the ability of these cells to synthesize insulin. (B) FD condition could render RINm5F cells to loss their abilities to secrete insulin in response to glucose challenge. The values shown are mean ± standard deviation (n = 3 of individual experiments). *p<0.05 v.s. control.