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. 2013 Nov 4;8(11):e77533. doi: 10.1371/journal.pone.0077533

Figure 3. In vitro growth initiation of non-growing oocytes in PTEN specific inhibitor, bpV incorporated culture.

Figure 3

(A) In vitro growth rates trended increase dependent on concentration of bpV, and were significantly higher in 14 and 140 µmol/l bpV groups (a,b P<0.05) (See Table S1 in detail). (B) The oocytes in 0, 0.14, 1.4 and 14 µmol/l bpV groups showed survival up to day 4 of culture, while in the 140 µmol/l bpV group most of them survived during only two days after culture. (C) Average diameters of the oocytes in 14 and 14 µmol/l bpV cultured groups increased significantly during culture. (D) Western blotting of phosphorylated Akt shows strongly detection in the specimens from the ovaries cultured with bpV for 24 hours dependent on bpV concentration.