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. 2009 Jun;101(6):3192–3198. doi: 10.1152/jn.91111.2008

FIG. 4.

FIG. 4.

Stress increases the linearity of the AMPAR receptor I-V relationship in NAc shell MSNs. A: AMPAR current-voltage relationship for neurons shown in B. B: rectification index (I−70mV/I+40mV) showing reduced AMPAR current rectification in stressed animals relative to controls (*P < 0.05). C: sample traces showing the effects of 1-naphthylacetyl spermine trihydrochloride (Naspm; 100–200 μM) on evoked AMPAR EPSCs recorded at −70 mV from NAc MSNs of control and stressed mice. Scale bar: 25 pA, 30 ms. D: the effects of Naspm application on evoked AMPAR EPSCs reported as EPSC amplitude following 8 to 10 min drug wash in normalized to baseline EPSC amplitude. Naspm-mediated reduction of AMPAR EPSC amplitudes was greater in controls than in stressed mice (*P < 0.01).