Table 2. Correlation between CXCR3 and CCR5 polymorphisms and outcome.
|
CXCR3
rs2280964 |
|
CR |
PR |
NR |
All,
n=141
n
(%) |
Responsea
(CR>PR>NR) |
Objective responseb(OR
vs
NR) |
Complete responseb(CR
vs
non-CR) |
|---|---|---|---|---|---|---|---|---|
| C (CC or C/-) | C/T vs T+C | C/T vs T+C Odds ratio (95% CI) | C/T vs T+C Odds ratio (95% CI) | |||||
| All | n (%) | 15 (17) | 26 (30) | 46 (53) | 87 (62) | All=1.28 (0.54–3.01) | All=0.83 (0.26–2.67) | |
| Male | n (%) | 9 (14) | 21 (33) | 33 (52) | 63 (45) | Female=1.26 (0.43–3.70) | Female=0.64 (0.16–2.58) | |
| Female |
n (%) |
6 (25) |
5 (21) |
13 (54) |
24 (17) |
P-value |
P-value |
P-value |
| All=0.75 | All=0.58 | All=0.75 | ||||||
| |
|
|
|
|
|
Female=0.94 |
Female=0.68 |
Female=0.52 |
|
CT |
|
|
|
|
|
C+ C/T
vs
T |
C+ C/T
vs
T
Odds ratio (95% CI) |
C+C/T
vs
T
Odds ratio (95% CI) |
| All (female) | n (%) | 4 (15) | 10 (39) | 12 (46) | 26 (18) | All=0.95 (0.39–2.29) | All=0.77 (0.26–2.31) | |
| Male=1.00 (0.37–2.27) | Male=0.53 (0.16–1.82) | |||||||
| |
|
|
|
|
|
|
Female=0.50 (0.04–5.87) |
Female=1.81 (0.08–37.93) |
|
T (TT or T/-) |
|
|
|
|
|
P-value |
P-value |
P-value |
| All | n (%) | 5 (21) | 7 (29) | 12 (50) | 24 (17) | All=0.80 | All=0.91 | All=0.77 |
| Male=0.73 | Male=1.00 | Male=0.32 | ||||||
| |
|
|
|
|
|
Female=0.92 |
Female=1.00 |
Female=1.00 |
| Male | n (%) | 5 (24) | 5 (24) | 11 (52) | 21 (15) | C vs T+T/C | C vs T+T/C | |
| Female |
n (%) |
0 (0) |
2 (67) |
1 (33) |
3 (2) |
C
vs
T+T/C |
Odds ratio (95% CI) |
Odds ratio (95% CI) |
| All=0.82 (0.41–1.65) | All=0.95 (0.38–2.36) | |||||||
| Male=1.00 (0.37–2.69) | Male=0.53 (0.16–1.82) | |||||||
| |
|
|
|
|
|
|
Female=0.69 (0.23–2.04) |
Female=2.08 (0.51–8.47) |
| |
|
|
|
|
|
P-value |
P-value |
P-value |
| All=0.64 | All=0.59 | All=1.00 | ||||||
| Male=0.73 | Male=1.00 | Male=0.32 | ||||||
| |
|
|
|
|
|
Female=0.90 |
Female=0.49 |
Female=0.48 |
|
CCR5-Δ32 |
|
CR |
PR |
NR |
All,
n=141
n
(%) |
Response (CR>PR>NR) |
Objective response (OR
vs
NR) |
Complete response (CR
vs
non-CR) |
| Δ32 |
|
|
|
|
|
|
Δ32
vs
WT
Odds ratio (95% CI) |
Δ32
vs
WT
Odds ratio (95% CI) |
| All |
n (%) |
6 (24) |
11c (44) |
8 (32) |
25 (18) |
|
2.53 (1.01–6.32) |
1.61 (0.57–4.57) |
|
WT |
|
|
|
|
|
P-value |
P-value |
P-value |
| All | n (%) | 19 (16) | 34 (29) | 63 (54) | 116 (82) | 0.058 | 0.043 | 0.37 |
Abbreviations: CI=confidence interval; CR=complete response; Non-CR=PR+NR; NR=no response; OR=objective response (CR+PR); PR=partial response; WT=wild-type.
One sample (PR) was not available for genotyping. As the CXCR3 gene is located on the X chromosome, the association between CXCR3 rs2280964 genotype and response was also separately evaluated in men and women. The four (men) patients carrying rs2280964 G allele (one CR, two PR, one NR) were not included in the correlative analysis.
a
P-values are from the Kruskall–Wallis test.
b
P-values are from the χ2-test or Fisher's exact test, as appropriate.
c
Included one patient homozygous for Δ32 polymorphism.