Table 3. Adverse events occurring in ⩾10% of patients.
| |
Total (n=30) |
|||
|---|---|---|---|---|
| Adverse events | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Neutropeniaa |
5 (20%) |
2 (7%) |
3 (10%) |
1 (3%) |
| Anaemia |
10 (33%) |
4 (13%) |
1 (3%) |
0 (0%) |
| Thrombocytopenia |
10 (33%) |
0 (0%) |
1 (3%) |
2 (7%) |
| Anorexia |
6 (20%) |
4 (13%) |
0 (0%) |
0 (0%) |
| Nausea |
17 (57%) |
1 (3%) |
0 (0%) |
0 (0%) |
| Vomiting |
9 (30%) |
2 (7%) |
1 (3%) |
0 (0%) |
| Dyspepsia |
5 (17%) |
6 (20%) |
0 (0%) |
0 (0%) |
| Stomatitis |
2 (7%) |
5 (17%) |
0 (0%) |
0 (0%) |
| Diarrhoea |
14 (47%) |
3 (10%) |
2 (7%) |
0 (0%) |
| Asthenia |
9 (30%) |
3 (10%) |
6 (20%) |
0 (0%) |
| Skin rash |
7 (23%) |
2 (7%) |
0 (0%) |
0 (0%) |
| Elevation of AST |
10 (33%) |
2 (7%) |
0 (0%) |
0 (0%) |
| Elevation of ALT |
12 (40%) |
2 (7%) |
1 (3%) |
0 (0%) |
| Hyperbilirubinaemia |
2 (7%) |
1 (3%) |
0 (0%) |
0 (0%) |
| Increased creatinine |
3 (10%) |
2 (7%) |
0 (0%) |
0 (0%) |
| Hypertriglyceridaemia |
4 (13%) |
1 (3%) |
3 (10%) |
0 (0%) |
| Hypertension |
7 (23%) |
4 (13%) |
2 (7%) |
0 (0%) |
| Proteinuria |
3 (10%) |
6 (20%) |
1 (3%) |
0 (0%) |
| Headache |
5 (17%) |
1 (3%) |
0 (0%) |
0 (0%) |
| Abdominal pain | 6 (20%) | 6 (20%) | 0 (0%) | 0 (0%) |
Abbreviations: AST=aspartate aminotransferase; ALT=alanine aminotransferase.
a
No patient had febrile neutropenia.